<p>Parkinson's disease covers a wide spectrum of symptoms, ranging from early non-motor symptoms to the characteristic bradykinesia, tremor and rigidity. Although differences in the symptomatology of Parkinson's disease are increasingly recognized, there is still a lack of insight into the heterogeneity of the pre-diagnostic phase of Parkinson's disease. In this perspective, we highlight three aspects regarding the role of population-based studies in providing new insights into the heterogeneity of pre-diagnostic Parkinson's disease. First we describe several specific advantages of population-based cohort studies, including the design which overcomes some common biases, the broad data collection and the high external validity. Second, we draw a parallel with the field of Alzheimer's disease to provide future directions to uncover the heterogeneity of pre-diagnostic Parkinson's disease. Finally, we anticipate on the emergence of prevention and disease-modification trials and the potential role of population-based studies herein. In the coming years, bridging gaps between study designs will be essential to make vital advances in elucidating the heterogeneity of pre-diagnostic Parkinson's disease.</p>

doi.org/10.3389/fneur.2021.702502, hdl.handle.net/1765/136245
Frontiers in Neurology
Erasmus MC: University Medical Center Rotterdam

L.J. (Lisanne) Dommershuijsen, A.J.W. (Agnita) Boon, & M.K. (Kamran) Ikram. (2021). Probing the Pre-diagnostic Phase of Parkinson's Disease in Population-Based Studies. Frontiers in Neurology, 12. doi:10.3389/fneur.2021.702502