<p>We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. Long-term treatment showed no clear evidence of the development of drug resistance. Gene silencing of importin-α1, a cellular target of ivermectin and a key member of the host nuclear transport complex, inhibited viral replication and largely abolished the anti-HEV effect of ivermectin.</p>

doi.org/10.1007/s00705-021-05096-w, hdl.handle.net/1765/136339
Archives of Virology
Erasmus MC: University Medical Center Rotterdam

Y. (Yunlong) Li, Z. (Zhijiang) Miao, P. (Pengfei) Li, R. (Ruyi) Zhang, Denis E. Kainov, Zhongren Ma, … Q. (Qiuwei) Pan. (2021). Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1. Archives of Virology, 166(7), 2005–2010. doi:10.1007/s00705-021-05096-w