Multislice computed tomography (MSCT) of the coronary arteries has emerged as a non-invasive modality for the diagnostic work-up of coronary artery disease. A complete MSCT study of the coronary arteries (Chapter 2) usually consists of two parts, a non-enhanced scan followed by a contrast-enhanced acquisition. Non-enhanced MSCT is used for measuring coronary artery calcium score. Contrast-enhanced MSCT coronary angiography (MSCT-CA) is used for the detection of coronary artery stenosis, in-stent restenosis, graft pathology and anatomical variants and anomalies of the coronary arteries (Chapters 8-19).