<p>Cerebral cortical microinfarcts (CMI) are small ischemic lesions that are associated with cognitive impairment and probably have multiple etiologies. Cerebral hypoperfusion has been proposed as a causal factor. We studied CMI in patients with internal carotid artery (ICA) occlusion, as a model for cerebral hemodynamic compromise. We included 95 patients with a complete ICA occlusion (age 66.2 ± 8.3, 22% female) and 125 reference participants (age 65.5 ± 7.4, 47% female). Participants underwent clinical, neuropsychological, and 3 T brain MRI assessment. CMI were more common in patients with an ICA occlusion (54%, median 2, range 1–33) than in the reference group (6%, median 0; range 1–7; OR 14.3; 95% CI 6.2–33.1; p&lt;.001). CMI were more common ipsilateral to the occlusion than in the contralateral hemisphere (median 2 and 0 respectively; p&lt;.001). In patients with CMI compared to patients without CMI, the number of additional occluded or stenosed cervical arteries was higher (p=.038), and cerebral blood flow was lower (B −6.2 ml/min/100 ml; 95% CI −12.0:–0.41; p=.036). In conclusion, CMI are common in patients with an ICA occlusion, particularly in the hemisphere of the occluded ICA. CMI burden was related to the severity of cervical arterial compromise, supporting a role of hemodynamics in CMI etiology.</p>

doi.org/10.1177/0271678X211011288, hdl.handle.net/1765/136707
Journal of Cerebral Blood Flow and Metabolism
Erasmus MC: University Medical Center Rotterdam

Heart-Brain Connection Consortium, Hilde van den Brink, Doeschka A. Ferro, Jeroen de Bresser, E.E. (Esther) Bron, Laurien P. Onkenhout, … Geert Jan Biessels. (2021). Cerebral cortical microinfarcts in patients with internal carotid artery occlusion. Journal of Cerebral Blood Flow and Metabolism, 41(10), 2690–2698. doi:10.1177/0271678X211011288