2021-10-01
Cardiovascular implantable electronic device therapy in patients with left ventricular assist devices
Publication
Publication
International Journal of Cardiology , Volume 340 p. 26- 33
<p>Background: There is conflicting observational data on the survival benefit cardiac implantable electronic devices (CIED) in patients with LVADs. Methods: Patients in whom an LVAD was implanted between January 2008 and April 2017 in the multinational Trans-Atlantic Registry on VAD and Transplant (TRAViATA) registry were separated into four groups based on the presence of CIED prior to LVAD implantation: none (n = 146), implantable cardiac defibrillator (ICD) (n = 239), cardiac resynchronization without defibrillator (CRT-P) (n = 28), and CRT with defibrillator (CRT-D) (n = 111). Results: A total of 524 patients (age 52 years ±12, 84.4% male) were followed for 354 (interquartile range: 166–701) days. After multivariable adjustment, there were no differences in survival across the groups. In comparison to no device, only CRT-D was associated with late right ventricular failure (RVF) (hazard ratio 2.85, 95% confidence interval [CI] 1.42–5.72, p = 0.003). There was no difference in risk of early RVF across the groups or risk of ICD shocks between those with ICD and CRT-D. Conclusion: In a multinational registry of patients with LVADs, there were no differences in survival with respect to CIED subtype. However, patients with a pre-existing CRT-D had a higher likelihood of late RVF suggesting significant long-term morbidity in those with devices capable of LV‑lead pacing post LVAD implantation.</p>
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| doi.org/10.1016/j.ijcard.2021.08.033, hdl.handle.net/1765/136731 | |
| International Journal of Cardiology | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Douglas Darden, Enrico Ammirati, Michela Brambatti, Andrew Lin, Jonathan C. Hsu, Palak Shah, … Oscar Braun. (2021). Cardiovascular implantable electronic device therapy in patients with left ventricular assist devices. International Journal of Cardiology, 340, 26–33. doi:10.1016/j.ijcard.2021.08.033 |
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