<p>Objectives: To validate novel dedicated 3D-QCA based on the software to calculate post PCI vessel-FFR (vFFR) in a consecutive series of patients, to assess the diagnostic accuracy, and to assess inter-observer variability. Background: Low post percutaneous coronary intervention (PCI) fractional flow reserve (FFR) predicts future adverse cardiac events. However, FFR assessment requires the insertion of a pressure wire in combination with the use of a hyperemic agent. Methods: FAST POST study is an observational, retrospective, single-center cohort study. One hundred patients presenting with stable angina or non ST-elevation myocardial infarction, who underwent post PCI FFR assessment using a dedicated microcatheter were included. Two orthogonal angiographic projections were acquired to create a 3D reconstruction of the coronary artery using the CAAS workstation 8.0. vFFR was subsequently calculated using the aortic root pressure. Results: Mean age was 65±12 years and 70% were male. Mean microcatheter based FFR and vFFR were 0.91±0.07 and 0.91±0.06, respectively. A good linear correlation was found between FFR and vFFR (r = 0.88; p &lt;.001). vFFR had a higher accuracy in the identification of patients with FFR values &lt;0.90, AUC 0.98 (95% CI: 0.96-1.00) as compared with 3D-QCA AUC 0.62 (95% CI: 0.94-0.74). Assessment of vFFR had a low inter-observer variability (r = 0.95; p &lt;.001). Conclusion: 3D-QCA derived post PCI vFFR correlates well with invasively measured microcatheter based FFR and has a high diagnostic accuracy to detect FFR &lt;0.90 with low inter-observer variability.</p>

doi.org/10.1002/ccd.29311, hdl.handle.net/1765/136907
Catheterization and Cardiovascular Interventions
Erasmus MC: University Medical Center Rotterdam

K (Kaneshka) Masdjedi, LJC (Laurens) van Zandvoort, M (Matthew) Mercieca Balbi, R.M. (Rutger-jan) Nuis, JA (Janneke) Wilschut, R. (Roberto) Diletti, … J. (Joost) Daemen. (2021). Validation of novel 3-dimensional quantitative coronary angiography based software to calculate fractional flow reserve post stenting. Catheterization and Cardiovascular Interventions, 98(4), 671–677. doi:10.1002/ccd.29311