<p>Extracorporeal blood purification is considered an adjunct therapy in critically ill patients with life-threatening conditions such as sepsis and septic shock. It consists of cytokine removal, removal of endotoxins, a combination of both, or the removal of pathogens themselves. The latter technique was introduced for clinical application very recently. This case study describes a case of a 69-year-old female lung transplant recipient patient with a persistent VV-ECMO-related septic deep vein thrombosis with continuous renal replacement therapy-dependent acute kidney injury initiated on the Seraph®-100 Microbind Affinity Filter in order to control the persistent bacteraemia with coagulase-negative staphylococci. Drug plasma concentrations (vancomycin, tacrolimus, and mycophenolic acid) were measured before and after the device to calculate absorber-related drug clearance. </p>

doi.org/10.1159/000514523, hdl.handle.net/1765/136931
Blood Purification
Erasmus MC: University Medical Center Rotterdam

H.R.H. (Hilde) de Geus, T.J.L. (Tim) Smeets, R.A.S. Hoek, H. (Rik) Endeman, & N.G.M. (Nicole) Hunfeld. (2021). The Seraph®-100 Microbind Affinity Blood Filter Does Not Affect Vancomycin, Tacrolimus, and Mycophenolic Acid Plasma Concentrations. Blood Purification, 50(6), 971–975. doi:10.1159/000514523