<p>Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and sur-gery. However, treatment is associated with low success rates. Therefore, there is a need to identify novel treatments for mycetoma. CIN-102 is a synthetic partial copy of cinnamon oils with activity against many pathogenic bacteria and fungi. In this study we determined the in vitro activity of CIN-102 against 21 M. mycetomatis isolates and its in vivo efficacy in a M. mycetomatis infected Galleria mellonella larval model. In vitro, CIN-102 was active against M. mycetomatis with MICs ranging from 32 μg/mL to 512 μg/mL. 128 μg/mL was needed to inhibit the growth in 50% of tested isolates. In vivo, concentrations below the MIC of 40 mg/kg and 80 mg/kg CIN-102 prolonged larval survival, but higher concentrations of CIN-102 did not.</p>

doi.org/10.1371/journal.pntd.0009488, hdl.handle.net/1765/136964
PLoS Neglected Tropical Diseases
Erasmus MC: University Medical Center Rotterdam

M. (Mickey) Konings, K. (Kimberly) Eadie, W. (Wilson) Lim, Ahmed H. Fahal, JW (Johan) Mouton, Nicolas Tesse, & W.W.J. (Wendy) Laureijssen - van de Sande. (2021). The synthetic synergistic cinnamon oil cin-102 is active against madurella mycetomatis, the most common causative agent of mycetoma. PLoS Neglected Tropical Diseases, 15(6). doi:10.1371/journal.pntd.0009488