RATIONALE: Tumor hypoxia has both prognostic and therapeutic consequences for solid tumors. We developed a novel noninvasive technique, differential path-length spectroscopy (DPS), which allows the measurement of hypoxia-related parameters in the superficial microvasculature of tissue. OBJECTIVES: The aim of this study was to measure the microvascular oxygenation of histologically normal endobronchial mucosa and of neoplastic lesions during bronchoscopy using DPS. METHODS: Sixty-four patients with known or suspected malignancies of the lung were studied. One hundred and five endobronchial lesions (38 histologically normal, 37 metaplastic/mild dysplastic lesions, and 30 invasive carcinomas) were detected by white and/or autofluorescence bronchoscopy and measured using DPS. RESULTS: We observed that bronchial tumors are characterized by a lower blood oxygen saturation and a higher blood content than normal mucosa. No differences were observed between normal and metaplastic/mild dysplastic mucosa. CONCLUSION: DPS is a new optical technique allowing the noninvasive study of endobronchial tumor hypoxia.

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doi.org/10.1164/rccm.200501-046OC, hdl.handle.net/1765/13700
American Journal of Respiratory and Critical Care Medicine
Erasmus MC: University Medical Center Rotterdam

Bard, M., Amelink, A., Hegt, V. N., Graveland, W., Sterenborg, D., Hoogsteden, H., & Aerts, J. (2005). Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy. American Journal of Respiratory and Critical Care Medicine, 171(10), 1178–1184. doi:10.1164/rccm.200501-046OC