<p>Context: Adult obesity is associated with chronic low-grade inflammation and may give rise to future chronic disease. However, it is unclear whether adiposity-related inflammation is already apparent in childhood. <br/></p><p>Objective: To study associations between child adiposity measures with circulating monocytes and naive and memory subsets in CD4, CD8, and γδT cell lineages. <br/></p><p>Methods: Ten-year-old children (n = 890) from the Generation R Cohort underwent dual-energy x-ray absorptiometry and magnetic resonance imaging for body composition (body mass index [BMI], fat mass index [FMI], android-to-gynoid fat mass ratio, visceral fat index, liver fat fraction). Blood samples were taken for detailed immunophenotyping of leukocytes by 11-color flow cytometry. <br/></p><p>Results: Several statistically significant associations were observed. A 1-SD increase in total FMI was associated with +8.4% (95% CI 2.0, 15.2) Vδ2+Vγ9+ and +7.4% (95% CI 2.4, 12.5) CD8+TEMRO cell numbers. A 1-SD increase in visceral fat index was associated with +10.7% (95% CI 3.3, 18.7) Vδ2+Vγ9+ and +8.3% (95% CI 2.6, 14.4) CD8+TEMRO cell numbers. Higher android-to-gynoid fat mass ratio was only associated with higher Vδ2+Vγ9+ T cells. Liver fat was associated with higher CD8+TEMRO cells but not with Vδ2+Vγ9+ T cells. Only liver fat was associated with lower Th17 cell numbers: a 1-SD increase was associated with -8.9% (95% CI -13.7, -3.7) Th17 cells. No associations for total CD8+, CD4+ T cells, or monocytes were observed. BMI was not associated with immune cells. <br/></p><p>Conclusion: Higher Vδ2+Vγ9+ and CD8+TEMRO cell numbers in children with higher visceral fat index could reflect presence of adiposity-related inflammation in children with adiposity of a general population.</p>

doi.org/10.1210/clinem/dgab433, hdl.handle.net/1765/137135
Journal of Clinical Endocrinology and Metabolism
Erasmus MC: University Medical Center Rotterdam

K.I.M. (Kirsten) Looman, S.M. (Susana) Moreira da Silva Santos, H.A. (Henriette) Moll, Charlotte W.E. Leijten, C. (Christina) Grosserichter - Wagener, R.G. (Trudy) Voortman, … JC (Jessica) Kiefte - de Jong. (2021). Childhood Adiposity Associated with Expanded Effector Memory CD8+and Vδ2+Vγ9+T Cells. Journal of Clinical Endocrinology and Metabolism, 106(10), E3923–E3935. doi:10.1210/clinem/dgab433