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E.J. Ruijgrok (Elisabeth), M.H.A.M. Fens (Marcel), I.A.J.M. Bakker-Woudenberg (Irma), E.W.M. van Etten (Els) and A.G. Vulto (Arnold)

2006-05-01

Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis.

Publication

Publication

Antimicrobial Agents and Chemotherapy , Volume 50 - Issue 5 p. 1852- 1854

Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.

Additional Metadata
Keywords Amphotericin B/*administration & dosage/pharmacology, Animals, Antibiotics, Antifungal/*administration & dosage/pharmacology, Aspergillosis/*drug therapy, Aspergillus fumigatus/*drug effects, Biological Markers/metabolism, Injections, Intravenous, Liposomes, Lung Diseases, Fungal/*drug therapy/microbiology, Nebulizers and Vaporizers/microbiology, Rats, Severity of Illness Index, Treatment Outcome
Persistent URL doi.org/10.1128/AAC.50.5.1852-1854.2006, hdl.handle.net/1765/14000
Journal Antimicrobial Agents and Chemotherapy
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Ruijgrok, E., Fens, M., Bakker-Woudenberg, I., van Etten, E., & Vulto, A. (2006). Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis. Antimicrobial Agents and Chemotherapy, 50(5), 1852–1854. doi:10.1128/AAC.50.5.1852-1854.2006
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