Background and objective: Pompe disease is an inherited metabolic disorder caused by deficiency of acid α-glucosidase. All affected neonates have a severe hypertrophic cardiomyopathy, leading to cardiac failure and death within the first year of life. We investigated the presence and extent of cardiac involvement in children and adults with Pompe disease with the common c.-32-13T>G genotype to determine the usefulness of cardiac screening in these patients with relatively 'milder' phenotypes. Methods: Cardiac dimensions and function were evaluated through echocardiography, electrocardiography and Holter monitoring. The total group comprised 68 patients with Pompe disease, of whom 22 patients had disease onset before the age of 18. Results: Two patients (3%) had cardiac abnormalities possibly related to Pompe disease: Electrocardiography showed a Wolff-Parkinson-White pattern in an 8-year-old girl, and one severely affected adult patient had a mild hypertrophic cardiomyopathy. This hypertrophy did not change during treatment with recombinant human α-glucosidase. In addition, four adult patients showed minor cardiac abnormalities which did not exceed the prevalence in the general population and were attributed to advanced age, hypertension or pre-existing cardiac pathology unrelated to Pompe disease. Conclusions: Cardiac involvement is rare in Pompe patients with the common c.-32-13T>G genotype. The younger patients were not more frequently affected than the adults. Electrocardiographic evaluation appears to be appropriate as initial screening tool. Extensive cardiac screening seems indicated only if the electrocardiogram is abnormal or the patient has a history of cardiac disease.

Acid maltase deficiency, Acid α-glucosidase, Cardiomyopathy, Glycogen storage disease type II, Lysosomal storage disorder, Pompe disease
dx.doi.org/10.1016/j.jns.2008.07.013, hdl.handle.net/1765/14243
Journal of the Neurological Sciences
Erasmus MC: University Medical Center Rotterdam

van der Beek, N.A.M.E, Soliman, O.I.I, van Capelle, C.I, Geleijnse, M.L, Vletter, W.B, Kroos, M.A, … van der Ploeg, A.T. (2008). Cardiac evaluation in children and adults with Pompe disease sharing the common c.-32-13T>G genotype rarely reveals abnormalities. Journal of the Neurological Sciences, 275(1-2), 46–50. doi:10.1016/j.jns.2008.07.013