Malignancies are the second most frequent cause of death in children in the Netherlands. Every year approximately 500-600 children aged 0-18 years are diagnosed with cancer 1. Survival rates of children with malignancies have increased tremendously, particularly in the last decennium. The survival rate of children with acute lymphatic leukemia (ALL) for example, has risen to almost 85% 2. One of the reasons for the increase in survival has been stepwise improvement in combination chemotherapy. With the increased survival, more attention is now being paid to the unwanted side effects of the treatment. A number of chemotherapeutic agents used in the treatment of childhood malignancies have side effects that may lead to decreased motor performance. Especially the use of vincristine is mentioned as a cause of problems during, and also after completion of chemotherapy.

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Jurriaanse Stichting, KOCR, Transfergroep Rotterdam
R. Pieters (Rob)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Hartman, A. (2009, January 21). Motor Performance following Chemotherapy for Childhood Cancer. Retrieved from