The Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA) trial demonstrated the benefits of combined antihypertensive/ lipid-lowering treatment over antihypertensive treatment alone in hypertensive patients with ≥3 additional cardiovascular (CV) risk factors. We assessed the prevalence and treatment of patients with hypertension and ≥3 additional CV risk factors in The Netherlands and Italy in a retrospective cohort study using the Integrated Primary Care Information (IPCI) database in The Netherlands and the Health Search/ Thales Database (HSD) in Italy. Patients aged ≥16 years, with 1 year of valid database history, diagnosed and/or treated for hypertension (>140/90 mmHg) during 2000-2002 were included in the study. The IPCI and HSD populations consisted of ∼175 000 and ∼325 000 patients, respectively. The prevalence of hypertension increased from 20.3 to 22.3% in the IPCI, and from 19.0 to 21.8% in the HSD during 2000-2002. The prevalence of ≥3 concomitant risk factors among hypertensive patients increased from 31.2 and 31.1% in 2000 to 34.2 and 39.3% in 2002 in the IPCI and HSD, respectively. From 2000 to 2002, among hypertensive patients with ≥3 CV risk factors and no prior symptomatic CV disease (CVD) approximately 54-57% in the IPCI and 80-83% in the HSD received antihypertensive treatment. In these patients, the use of combined antihypertensive and lipid-lowering treatment increased from 14.2 to 17.6% in the IPCI and from 15.5 to 17.4% in the HSD from 2000 to 2002. This study shows that primary prevention of CVD in hypertensive patients in The Netherlands and Italy could be improved.

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Journal of Human Hypertension
Erasmus MC: University Medical Center Rotterdam

Sturkenboom, M., Dieleman, J., Picelli, G., Mazzaglia, G., Mozaffari, M., Filippi, A., … van der Lei, J. (2008). Prevalence and treatment of hypertensive patients with multiple concomitant cardiovascular risk factors in The Netherlands and Italy. Journal of Human Hypertension, 22(10), 704–713. doi:10.1038/jhh.2008.82