Characterization of an ectopic beta-globin LCR: Good neighbors and a distant friend
Analyse van een Ectopisch Geïntegreerde β -Globine LCR: Goede buren en een verre vriend
The work discussed in this thesis is aimed at answering questions related to nuclear and chromatin organization, and to functioning of the β-globin LCR. In the introduction these topics are introduced and questions regarding their function are being posed. In the following four experimental chapters, the functional role of the LCR on nuclear and chromatin organization is addressed. In all chapters, the framework for the study is shortly introduced and the results are discussed within this framework. In Chapter 7, general conclusions are drawn from the total work in this thesis.