In vitro comparison of isometric and stop-test contractility parameters for the urinary bladder
Contractility parameters in the urinary bladder can be calculated from isometric contractions (no extra patient load as compared to routine cystometry) or from stop-tests (more accurate, simpler analysis). A stop-test involves a voluntarily interrupted micturition with pressure and flow measurement. In a series of measurements in vitro on pig urinary bladder strips, parameters of the first type, obtained either by analyzing isometric contractions in terms of the Hill model, or by making phase plots, were compared to parameters of the second type. A good correlation was found. Th parameter correlating best with the maximal contraction velocity of the bladder, normalized for differences in initial muscle length, as obtained from stop-test, is the isometric contraction force, which can be obtained from an isometric contraction by either of the two analysis techniques. Clinically, making phase plots seems more promising than analyzing contractions in terms of the Hill model.
|*Muscle Contraction, Animals, Electric Stimulation, Isometric Contraction, Muscle, Smooth/physiology, Swine, Urinary Bladder/*physiology|
|Urological Research: a journal of clinical and laboratory investigation in urolithiasis and related areas|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
van Mastrigt, R, & Glerum, J.J. (1985). In vitro comparison of isometric and stop-test contractility parameters for the urinary bladder. Urological Research: a journal of clinical and laboratory investigation in urolithiasis and related areas, 11–17. doi:10.1007/BF00571750