Clear cell sarcoma (CCS), also known as clear cell sarcoma of tendons and aponeuroses or malignant melanoma of soft tissue, is a rare malignant tumor and is histogenitically related to melanoma. The aim of this study was to describe our experience with the sentinel node (SN) procedure for CCS patients and to discuss the potential value of this technique for CCS patients. Five patients with a subcutaneous CCS, who underwent an SN procedure, are described. Two patients had positive SNs, with additional tumor positive nodes in both lymph node dissection specimens. Only the patients with tumor positive SNs developed recurrent disease during an average follow-up of 33 months. None of the negative SN patients developed recurrent disease and all were alive after an average follow-up of 39 months. SN status seems to predict additional nodal involvement and recurrent disease as well as survival. The SN procedure might be a useful and accurate staging procedure in CCS patients, comparable to the situation in melanoma.

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Journal European Journal of Surgical Oncology
van Akkooi, A.C.J, Verhoef, C, van Geel, A.N, Kliffen, M, Eggermont, A.M.M, & de Wilt, J.H.W. (2006). Sentinel node biopsy for clear cell sarcoma. European Journal of Surgical Oncology, 32(9), 996–999. doi:10.1016/j.ejso.2006.03.044