The main issue addressed in this thesis is how different levels of signaling activity of the Wnt and TGF-β/BMP pathways can affect transcriptional responses in particular relevant for self-renewal and differentiation both in homeostasis and in cancer. Chapter 1 presents an overview of the existent literature leading to the formulation of the hypothesis that Apc/Wnt pathway acts in a dosage-dependent manner both in normal and neoplastic tissues.

Apc, beta-catenin, cancer, dosage, mammary gland, wnt
R. Fodde (Riccardo)
Erasmus University Rotterdam
Dutch Cancer Society (KWF),Netherlands Organization for Scientifi c Research (NWO),BSIK Innovation programme “Stem Cells in Development and Disease” (SCDD, BSIK 03038),EUFP6 Migrating Cancer Stem Cells program (MCSCs),Association for International Cancer Research (AICR),Erasmus MC,Josephine Nefkens Institute.
This work was funded by the European Commission 7th Framework Programme; grant id fp7/201662 - An integrated concept of tumor metastasis: implications for therapy (TUMIC)
Erasmus MC: University Medical Center Rotterdam

Gaspar, C.F.C. (2009, February 26). Signaling Pathways in Cancer: a Matter of Dosage. Erasmus University Rotterdam. Retrieved from