The main issue addressed in this thesis is how different levels of signaling activity of the Wnt and TGF-β/BMP pathways can affect transcriptional responses in particular relevant for self-renewal and differentiation both in homeostasis and in cancer. Chapter 1 presents an overview of the existent literature leading to the formulation of the hypothesis that Apc/Wnt pathway acts in a dosage-dependent manner both in normal and neoplastic tissues.

Apc, beta-catenin, cancer, dosage, mammary gland, wnt
R. Fodde (Riccardo)
Erasmus University Rotterdam
Dutch Cancer Society (KWF),Netherlands Organization for Scientifi c Research (NWO),BSIK Innovation programme “Stem Cells in Development and Disease” (SCDD, BSIK 03038),EUFP6 Migrating Cancer Stem Cells program (MCSCs),Association for International Cancer Research (AICR),Erasmus MC,Josephine Nefkens Institute.
978-90-90-23985-9
hdl.handle.net/1765/14964
This work was funded by the European Commission 7th Framework Programme; grant id fp7/201662 - An integrated concept of tumor metastasis: implications for therapy (TUMIC)
Erasmus MC: University Medical Center Rotterdam

Gaspar, C.F.C. (2009, February 26). Signaling Pathways in Cancer: a Matter of Dosage. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/14964