The dose effect (0, 10, 20 and 60 micrograms) of influenza subunit vaccine on the antibody response was investigated in nursing-home residents and young controls. The vaccine antigens were: A/Taiwan/1/86 (H1N1), A/Sichuan/2/87 (H3N2) and B/Beijing/1/87. For the influenza B antigen, the post-GMT and the 'percentage protective titre' increased significantly both in the young controls and nursing-home residents. No dose effect was observed for the A/Taiwan, and a minor dose effect for A/Sichuan. All vaccine doses were well tolerated by both groups. We conclude from our data that higher vaccine doses may result in a better antibody response against some antigens but not against others. Therefore, in general, increasing the vaccine dose is no adequate method to improve the antibody response.

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Erasmus MC: University Medical Center Rotterdam

Palache, A., Beyer, W., Sprenger, M., Masurel, N., de Jonge, S., Vardy, A., … Rubinstein, E. (1993). Antibody response after influenza immunization with various vaccine doses. Vaccine, 11(1), 3–9. doi:10.1016/0264-410X(93)90333-S