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W.E.Ph. Beyer (Walter), R.W.H. Ruigrok, H. van Driel and N. Masurel (Nic)

1986

Influenza virus strains with a fusion threshold of pH 5.5 or lower are inhibited by amantadine. Brief report

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Publication

Archives of Virology p. 173- 181

Nineteen influenza virus strains were examined for susceptibility to amantadine-HCl (AMT) and for pH-thresholds of haemagglutinin-induced haemolysis. Whereas pH-thresholds below 5.5 were not seen in AMT-resistant strains, AMT-sensitive strains showed pH-thresholds either below or above 5.5.

Additional Metadata
Keywords *Cell Fusion, Amantadine/*pharmacology, Animals, Cell Line, Drug Resistance, Endocytosis, Haplorhini, Hemagglutinin Glycoproteins, Influenza Virus, Hemagglutinins, Viral/physiology, Hemolytic Plaque Technique, Hydrogen-Ion Concentration, Kidney, Orthomyxoviridae/*drug effects/physiology, Protein Conformation
Persistent URL doi.org/10.1007/BF01314156, hdl.handle.net/1765/15004
Journal Archives of Virology
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Beyer, W., Ruigrok, R. W. H., van Driel, H., & Masurel, N. (1986). Influenza virus strains with a fusion threshold of pH 5.5 or lower are inhibited by amantadine. Brief report. Archives of Virology, 173–181. doi:10.1007/BF01314156
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