Influenza virus strains with a fusion threshold of pH 5.5 or lower are inhibited by amantadine. Brief report
Archives of Virology p. 173- 181
Nineteen influenza virus strains were examined for susceptibility to amantadine-HCl (AMT) and for pH-thresholds of haemagglutinin-induced haemolysis. Whereas pH-thresholds below 5.5 were not seen in AMT-resistant strains, AMT-sensitive strains showed pH-thresholds either below or above 5.5.
|*Cell Fusion, Amantadine/*pharmacology, Animals, Cell Line, Drug Resistance, Endocytosis, Haplorhini, Hemagglutinin Glycoproteins, Influenza Virus, Hemagglutinins, Viral/physiology, Hemolytic Plaque Technique, Hydrogen-Ion Concentration, Kidney, Orthomyxoviridae/*drug effects/physiology, Protein Conformation|
|Archives of Virology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Beyer, W.E.Ph, Ruigrok, R.W.H, van Driel, H, & Masurel, N. (1986). Influenza virus strains with a fusion threshold of pH 5.5 or lower are inhibited by amantadine. Brief report. Archives of Virology, 173–181. doi:10.1007/BF01314156