In the autumn of 1992 two-thirds of the population of a nursing home in Amsterdam was vaccinated against influenza. However, in March 1993 an outbreak of an influenza like illness occurred with a morbidity rate of 49% and a mortality rate of 10%. There was sufficient serological evidence to show that the vaccine as such had induced adequate immunity. As the causative agent an influenza A/H3N2 virus was identified. The failing activity of the vaccine in this instance was apparently caused by the absence of sufficient antigen similarity between the A/H3N2 vaccine component and the epidemic virus ('vaccine mismatch').

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Nederlands Tijdschrift voor Geneeskunde
Erasmus MC: University Medical Center Rotterdam

Beyer, W., Bakker, G., van Beek, R., & Masurel, N. (1993). Influenza-epidemie in een verpleeghuis door een virus dat niet in het vaccin was opgenomen. Nederlands Tijdschrift voor Geneeskunde, 1973–1977. Retrieved from