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E.Z. Loizidou (Eriketi), I. Kousiappa (Ioanna), C.D. Zeinalipour-Yazdi (Constantinos), D.A.M.C. van de Vijver (David) and L.G. Kostrikis (Leondios)

2009-01-13

Implications of HIV-1 M group polymorphisms on integrase inhibitor efficacy and resistance

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Genetic and structural in silico analyses

Biochemistry , Volume 48 - Issue 1 p. 4- 6

The extensive polymorphisms among HIV-1 subtypes have been implicated in drug resistance development. Integrase inhibitors represent the latest addition to the treatment of HIV-1, and their efficacy and resistance patterns among M group strains are currently under investigation. This study analyzed the intersubtype variation within 108 integrase sequences from seven subtypes. The residues associated with catalytic activity and primary resistance to raltegravir were highly conserved among all strains. Variations were observed in residues associated with secondary resistance. Molecular modeling studies indicated a two-way binding mode of raltegravir that explains the resistance pathways and the implication of nonconservative mutations in integrase-raltegravir interactions. © 2009 American Chemical Society.

Additional Metadata
Keywords Binding Sites, Binding energy, Binding modes, Catalytic activities, Drug Resistance, Drug resistance, Genetic, HIV Integrase, HIV Integrase Inhibitors, HIV-1, In-silico, Integrase (IN), Models, Molecular, Molecular modeling studies, Mutation, Polymorphism, Protein Binding, Protein Conformation, Pyrrolidinones, Viral
Persistent URL doi.org/10.1021/bi8019349, hdl.handle.net/1765/15064
Journal Biochemistry
Grant This work was funded by the European Commission 7th Framework Programme; grant id fp7/204263 - Design, Synthesis and Biological Evaluation of HIV-1 and HCV inhibitors (ANTIVIRAL)
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Loizidou, E., Kousiappa, I., Zeinalipour-Yazdi, C., van de Vijver, D., & Kostrikis, L. (2009). Implications of HIV-1 M group polymorphisms on integrase inhibitor efficacy and resistance. Biochemistry, 48(1), 4–6. doi:10.1021/bi8019349
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