OBJECTIVES: To study the effect of two different frequencies of distraction on the quantity and architecture of bone regenerate using micro-computed tomography, and to determine whether radiographic and ultrasonographic bone-fill scores provide reliable predictive value for the amount of new bone in the distraction area. MATERIAL AND METHODS: Twenty-six skeletally mature rabbits underwent three full days of latency, after which midface distraction was started. Low-frequency group (n=12): a distraction rate of 0.9 mm/d achieved by one daily activation for 11 days to create a 10mm distraction gap. High-frequency group (n=12): idem, but three daily activations were used instead of one. Control group (n=2) underwent no distraction. After 21 days of consolidation, bone-fill in the distraction area was assessed by means of ultrasonography and radiography. Micro-computed tomography was used to quantify new bone formation and bone architecture. RESULTS: Relative bone volume (BV/TV) showed a tendency towards a difference (P=0.09) between the low and high-frequency groups. No significant differences were found for bone architecture. No significant correlation between BV/TV values and bone-fill scores was found. CONCLUSIONS: An increase in rhythm from one to three activations daily does not create significantly more bone. Bone-fill score values provided no reliable predictive value for the amount of new bone formation.

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In 2008: Department of Biomedical Engineering, Erasmus MC
doi.org/10.1016/j.jcms.2007.11.002, hdl.handle.net/1765/15242
Journal of Cranio-Maxillofacial Surgery
Erasmus MC: University Medical Center Rotterdam

Djasim, U., Wolvius, E., van Neck, H., Weinans, H., van der Wal, K., & van Wamel, A. (2008). Single versus triple daily activation of the distractor: no significant effects of frequency of distraction on bone regenerate quantity and architecture. Journal of Cranio-Maxillofacial Surgery, 36(3), 143–151. doi:10.1016/j.jcms.2007.11.002