Soft tissue sarcomas comprise approximately 1% of malignant tumors. There are more than 50 subtypes, but pleomorphic sarcoma, liposarcoma, leiomyosarcoma, synovial sarcoma, and malignant peripheral nerve sheath tumor account for 75%. Differentiation between these subtypes is difficult because they often present with a painless enlarging mass, and share many histological and MR imaging features. Nonetheless, subdifferentiation is important because the different subtypes have different prognoses and therapeutic strategies. In this manuscript we discuss the clinical, histological, and MR imaging features of soft tissue sarcomas according to the WHO classification. An overview is provided and differentiating features are discussed that can help to narrow down the differential diagnosis.

Histology, Magnetic resonance imaging, Soft tissue sarcoma, WHO
dx.doi.org/10.1007/s00330-008-1292-3, hdl.handle.net/1765/15341
European Radiology: journal of the European Congress of Radiology
Erasmus MC: University Medical Center Rotterdam

van Vliet, M.H, Kliffen, M, Krestin, G.P, & van Dijke, C.F. (2009). Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors. European Radiology: journal of the European Congress of Radiology, 19(6), 1499–1511. doi:10.1007/s00330-008-1292-3