Local gentamicin treatment in revision surgery for infected hip and knee prostheses is well established. It is a safe and effective method compared with the systemic use of aminoglycosides. Although nephrotoxic side effects are uncommon, we report a case of acute renal failure after 2-stage revision treatment of an infected knee prosthesis with gentamicin-impregnated beads and block spacers. The combined use of beads and a cement block spacer, both gentamicin impregnated, may have induced this severe complication. Use of this procedure in elderly patients warrants careful follow-up of renal function.

, , , , , , , , , , ,
doi.org/10.1054/arth.2002.34525, hdl.handle.net/1765/15613
Journal of Arthroplasty
Erasmus MC: University Medical Center Rotterdam

van Raaij, T., Visser, L., Vulto, A., & Verhaar, J. (2002). Acute renal failure after local gentamicin treatment in an infected total knee arthroplasty. Journal of Arthroplasty, 17(7), 948–950. doi:10.1054/arth.2002.34525