The aim of this study was to examine whether a well-known functional polymorphism in COMT (Val158Met) influences osteoarthritis (OA)–related pain.

article, catechol methyltransferase, clinical feature, disease course, dopamine, genetic association, genetic polymorphism, genetic variability, hip osteoarthritis, hip pain, hip radiography, human, noradrenalin, priority journal, protein expression,
Arthritis & Rheumatology
This work was funded by the European Commission 7th Framework Programme; grant id fp7/200800 - Translational Research in Europe – Applied Technologies for Osteoarthritis (TREAT OA)
Erasmus MC: University Medical Center Rotterdam

van Meurs, J.B.J, Uitterlinden, A.G, Stolk, L, Kerkhof, J.M, Hofman, A, Pols, H.A.P, & Bierma-Zeinstra, S.M. (2009). A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain. Arthritis & Rheumatology, 60(2), 628–629. doi:10.1002/art.24175