2002-01-30
Molecular Cloning and Pharmacology of Porcine 5-Hydroxytryptamine Receptors Relevant to the Study of Antimigraine Drugs
Publication
Publication
Moleculaire klonering en farmacologie van varken 5-hydroxytryptamine receptoren die relevant zijn voor geneesmiddelen-onderzoek voor migraine therapie
At the beginning of last century, Brodie (1900) described in an extensive study that injection of blood serum causes vasoconstriction and a vagally-mediated reflex resulting in a reversible bradycardia, hypotension and arrest of the respiration, while injection of blood plasma was devoid of these effects. About 50 years ago, the hormone and neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) was isolated from blood serum and named due to its origin and vascular action (sero=serum and tonin=vasoconstriction) (Rapport et al., 1948). Similarly, another endogenous substance from the enterochromaffin cells (present in gastrointestinal mucosa) was isolated, functionally characterised and named enteramine (Erspamer & Asero, 1952). The functional properties of enteramine were mainly smooth muscle contraction and further investigations revealed that enteramine and serotonin were chemically and pharmacologically similar (Erspamer, 1954).
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| Novartis Pharma AG. (Basel, Switzerland), Almirall Prodesfarma (Breda, The Netherlands), Nederlandse Hoofdpijn Vereniging, Erasmus Universiteit Rotterdam (Rotterdam, The Netherlands) | |
| P.R. Saxena (Pramod Ranjan) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/16166 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Bhalla, P. (2002, January 30). Molecular Cloning and Pharmacology of Porcine 5-Hydroxytryptamine Receptors Relevant to the Study of Antimigraine Drugs. Retrieved from http://hdl.handle.net/1765/16166 |
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