Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

angiogenesis, article, calcium binding, collagen, developmental stage, embryo, endothelial cell growth factor, endothelium cell, genetic screening, nonhuman, priority journal, protein domain, vascularization, vasculotropin C, zebra fish,
Nature Genetics
Erasmus MC: University Medical Center Rotterdam

Hogan, B.M, Bos, F.L, Bussmann, J, Witte, M, Chi, N.C, Duckers, H.J, & Schulte-Merker, S. (2009). Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nature Genetics, 41(4), 396–398. doi:10.1038/ng.321