Cerebellar stroke has been virtually unreported in the living newborn infant. A term newborn male weighing 3380 g at birth suffered myoclonic seizures within 24 hours of birth by spontaneous vaginal delivery. Apgar scores were 3 and 4 at 1 and 5 minutes. Myoclonus persisted for 9 days, responding poorly to step-up anticonvulsant treatment including lidocaine, midazolam, and clonazepam. Imaging documented arterial ischaemic stroke within the left posterior cerebral and both superior cerebellar arteries, compatible with top of the basilar artery stroke. There was no electrographic correlate for the seizures. Disturbed oscillation within the dentato-rubro-olivary circuitry was the likely mechanism. The probable cause was embolism from an in-utero-onset inferior caval vein thrombosis. At 22 months the child was sitting unsupported. Scores on the Bayley Scales of Infant Development II were equivalent to those of a 12-month-year-old. He showed ataxic motor behaviour. Embolism can cause neonatal top of the basilar artery stroke, which may present with myoclonus due to cerebellar injury.

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Keywords Apgar score, anamnesis, anterior cerebral artery, artery embolism, article, assisted ventilation, ataxia, basilar artery, case report, cerebrovascular accident, child, clonazepam, convergent strabismus, convulsion, diffusion weighted imaging, drug blood level, drug dose reduction, echoencephalography, homonymous hemianopia, human, hypersalivation, inferior cava vein obstruction, lidocaine, male, midazolam, middle cerebral artery, motor performance, muscle hypotonia, myoclonus, nuclear magnetic resonance imaging, phenobarbital, posterior cerebral artery, priority journal, psychomotor development, thrombosis
Persistent URL dx.doi.org/10.1111/j.1469-8749.2008.03183.x, hdl.handle.net/1765/16579
Journal Developmental Medicine and Child Neurology
Govaert, P, Dudink, J, Visser, G.H, Breukhoven, P.E, Vanhatalo, S, & Leguin, M. (2009). Top of the basilar artery embolic stroke and neonatal myoclonus. Developmental Medicine and Child Neurology, 51(4), 324–327. doi:10.1111/j.1469-8749.2008.03183.x