Does HPA-axis activity mediate the relationship between obstetric complications and externalizing behavior problems? the TRAILS study
To examine whether HPA-axis activity mediates the relationship between obstetric complications (OCs) and externalizing behavior problems, and to investigate whether this model is different for boys and girls. In a population-based cohort of 1,768 10- to 12-year-old early adolescents, we assessed the cortisol awakening response and evening cortisol levels. Externalizing behavior problems were assessed using the Child Behavior Checklist and the Youth Self-Report. OCs were retrospectively assessed in a parent interview. OCs significantly predicted externalizing behavior problems, but OCs did not predict HPA-axis activity. Thus, the mediation model was not supported. In addition to the relationship between HPA-axis activity and externalizing behavior problems, which is specific for girls, there is also a relationship between OCs and externalizing behavior problems. However, these two mechanisms are not related to each other indicating that HPA-axis activity is not a mediator in the relationship between OCs and externalizing behavior problems. Future research should focus on understanding the mechanism through which OCs cause externalizing behavior problems.
|Keywords||Cortisol, Early adolescence, Externalizing behavior problems, General population, Pre- and perinatal risk factors|
|Persistent URL||dx.doi.org/10.1007/s00787-009-0014-y, hdl.handle.net/1765/16895|
|Journal||European Child and Adolescent Psychiatry|
Marsman, R, Rosmalen, J.G.M, Oldehinkel, A.J, Ormel, J, & Buitelaar, J.K. (2009). Does HPA-axis activity mediate the relationship between obstetric complications and externalizing behavior problems? the TRAILS study. European Child and Adolescent Psychiatry, 18(9), 565–573. doi:10.1007/s00787-009-0014-y