Nuclear hormone receptors (NHRs) are intermediary factors through which extracellular signals regulate expression of genes that are involved in homeostasis, development, and differentiation (Beato et al. '995, Mangelsdorf and Evans 1995). These receptors are characterized by a modular structure, with domains involved in transcription activation, DNA binding. hormone binding, and dimerization. The nuclear receptor super-family comprises three subfamilies of receptors, which might have emerged early during evolution (Laudet et af. 1992).

androgeen receptor gen, gene mutations, nuclear hormone receptors
J.A. Grootegoed (Anton)
Erasmus University Rotterdam
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)
hdl.handle.net/1765/17005
Erasmus MC: University Medical Center Rotterdam

Brüggenwirth, H.T. (1998, June 12). Genetic and Functional Analysis of Androgen Receptor Gene Mutations. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/17005