During life the body is challenged by a wide variety of infectious agents. To combat and constrain infections with these agents the immune system uses a complex network of defence mechanisms. One of these is the ability to respond in a specific way (adaptive innnunity) to unique stmctures (antigens) of the agent or its products. Interestingly, many agents have developed ways to escape from, or suppress specific and non-specific immune effector mechanisms. The principle of vaccination, which was introduced more than 200 years ago by Edward Jenner (Willis, 1997), utilizes the ability of the immune system to develop a specific immune and/or memory response, before the body is exposed to the pathogen, thereby mimicking specific immunity induced by infection.

antigens (viral and bacterial), immunology, infectious diseases, vaccins
A.D.M.E. Osterhaus (Albert)
Erasmus University Rotterdam
Bayer BY, Beun de Ronde BV, BioMerieux Benelux BY, Biotrading Benelux BY, EUR Rotterdam, Eurovalid-Atihmius BY, ID-OLO, Intervet, Adviesburo Ka & Ko, Sigma-Aldrich, RIVM, TNO companies.
Erasmus MC: University Medical Center Rotterdam

Claassen, I.J.Th.M. (1998, December 9). Immunogenic presentation of viral and bacterial antigens: iscom and OMV as a basis for new vaccines. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/17011