Role of Staphylococcus aureus nasal colonization in atopic dermatitis in infants: The generation R study
Archives of Pediatrics & Adolescent Medicine , Volume 163 - Issue 8 p. 745- 749
Objective: To study the association between Staphylococcus aureus nasal colonization and atopic dermatitis (AD) in infancy. Design: Population-based prospective cohort study of pregnant women and their children. Setting: This project was embedded in the Generation R Study. Participants: A total of 1079 postnatal Dutch infants/ children participated in the focus cohort. Main Exposures: Nasal swabs for S aureus cultivation were taken at ages 1.5, 6, and 14 months. Main Outcome Measure: Questionnaires that pertain to AD and confounders (birth weight, gestational age, sex, and parental eczema) were completed prenatally and postnatally. The outcome was AD in the first and second years of life. Results: A first positive culture for S aureus at age 6 months was associated with AD prevalence in the first and second years of life (adjusted odds ratio [aOR], 2.13; 95% confidence interval [CI], 1.17-3.87; and aOR, 2.88; 95% CI, 1.60-5.19, respectively) and also with severity (aOR, 3.27; 95% CI, 1.30-8.03). Moreover, frequent colonization in the first year of life (≥2 times) held a 4.29-fold (95% CI, 1.03- to 17.88-fold) risk of moderate to severe AD in the second year of life. Conclusion: Colonization with S aureus at age 6 months and frequent colonization in the first year of life are associated with AD and its severity in young children.
|Staphylococcus aureus, article, atopic dermatitis, bacterial colonization, bacterium culture, bacterium isolation, child, disease association, disease severity, female, human, infant, major clinical study, male, nose, nose smear, prevalence, priority journal, prospective study, risk factor|
|Staphylococcus aureus: Resources|
|Archives of Pediatrics & Adolescent Medicine|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Lebon, A, Labout, J.A.M, Verbrugh, H.A, Jaddoe, V.W.V, Hofman, A, van Wamel, W.J.B, … Moll, H.A. (2009). Role of Staphylococcus aureus nasal colonization in atopic dermatitis in infants: The generation R study. Archives of Pediatrics & Adolescent Medicine, 163(8), 745–749. doi:10.1001/archpediatrics.2009.117