Traditionally the renin-angiotensin system (RAS) has been viewed as a circulating system. Circulating renin, released by the kidneys, cleaves liver-derived angiotensinogen, which yields the inactive decapeptide angiotensin I (Ang (1-10) or Ang I) (Figure 1). Ang I is subsequently converted into an octapeptide, angiotensin II (Ang (1-8) or Ang II), by angiotensin-converting enzyme (ACE), an enzyme that is either located at the huninal side of the endothelium or circulating freely in plasma. Ang II is rapidly metabolized by so-called angiotensinases.

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Netherlands Heart Foundation,Dr Saal van Zwanenberg Foundation
P.R. Saxena (Pramod Ranjan) , M.A.D.H. Schalekamp (Maarten)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

van Kesteren, T. (1998, December 17). (Pro)Renin Uptake and Prorenin Activation in the Cardiovascular System. Retrieved from