Hepatic lipase is synthesized and constitutively secreted by liver parenchymal cells (1-3), and is subsequently bound extracellularly in the space of Disse of the liver (4-6). The protein is also found in adrenals, ovaries and testes (7-10). However, in adrenals and ovaries an altered, shorter mRNA is expressed and no mature HL protein is synthesized (3, 9, 11, 12). Thus, liver parenchymal cells may uniquely synthesize and secrete a fully active HL. HL affects the metabolism of several lipoproteins and is thought to protect against the development of atherosclerosis (Chapter 1.1.1). Therefore it is of importance to understand the mechanisms which regulate HL expression. Several cell types serve as a model system for secretion ofHL (13-17). The studies described herein were performed with the human-derived HepG2 cell-line and freshly isolated rat hepatocytes.

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Netherlands Heart Foundation, Novo Nordisk
H. Jansen (Hans)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Neve, B. (1998, May 15). Hepatic Lipase: Regulation at the post-transcriptional level. Retrieved from http://hdl.handle.net/1765/17607