Linkage analysis of adult height in a large pedigree from a Dutch genetically isolated population
Human Genetics , Volume 126 - Issue 3 p. 457- 471
Despite extensive research of genetic determinants of human adult height, the genes identified up until now allow to predict only a small proportion of the trait's variance. To identify new genes we analyzed 2,486 genotyped and phenotyped individuals in a large pedigree including 23,612 members in 18 generations. The pedigree was derived from a young genetically isolated Dutch population, where genetic heterogeneity is expected to be low and linkage disequilibrium has been shown to be increased. Complex segregation analysis confirmed high heritability of adult height, and suggested mixed model of height inheritance in this population. The estimates of the model parameters obtained from complex segregation analysis were used in parametric linkage analysis, which highlighted three genome-wide significant and additionally at least four suggestive loci involved in height. Significant peaks were located at the chromosomal regions 1p32 (LOD score = 3.35), 2p16 (LOD score = 3.29) and 16q24 (LOD score = 3.94). For the latter region, a strong association signal (FDR q < 0.05) was obtained for 19 SNPs, 17 of them were located in the CDH13 (cadherin 13) gene of which one (rs1035569) explained 1.5% of the total height variance.
|South America, adult, article, body height, cadherin, cadherin 13, chromosome 16q, chromosome 1p, chromosome 2p, controlled study, female, gene identification, gene isolation, gene linkage disequilibrium, gene locus, genetic heterogeneity, genetic variability, genotype, heritability, human, linkage analysis, major clinical study, male, nucleotide sequence, pedigree, phenotype, population genetics, prediction, priority journal, segregation analysis, sex difference, single nucleotide polymorphism, unclassified drug, validity|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Axenovich, T.I, Zorkoltseva, I.V, Belonogova, N.M, Struchalin, M.V, Kirichenko, A.V, Kayser, M.H, … Aulchenko, Y.S. (2009). Linkage analysis of adult height in a large pedigree from a Dutch genetically isolated population. Human Genetics, 126(3), 457–471. doi:10.1007/s00439-009-0686-x