Gene Expression Profiling of Early Stage Non-Small Cell Lung Cancer

NSCLC is a highly heterogeneous malignancy with a poor prognosis. Treatment for NSCLC is currently based on a combination of pathological staging and histological classification. Recently, gene expression-based NSCLC profiling is proven a superior approach to stratify cancer cases with different prognosis and to sub-classify patients in respect of response to chemotherapy. The goal of the work described in this thesis is to explore the possible application of expression profiling in oncological practice.