Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1.2%) than in non-carriers (41/10588, 0.4%; relative risk 3.0, 95% CI 2.0-4.7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0.005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0.006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous

Bacteremia/*microbiology, Bacterial Typing Techniques, Carrier State/*microbiology, Cross Infection/microbiology/mortality/*transmission, Female, Hospital Mortality, Humans, Length of Stay, Male, Middle Aged, Nasal Cavity/*microbiology, Risk Factors, Staphylococcal Infections/microbiology/mortality/*transmission, Staphylococcus aureus/classification/*isolation & purification
dx.doi.org/10.1016/S0140-6736(04)16897-9, hdl.handle.net/1765/17750
Staphylococcus aureus: Resources
The Lancet
Erasmus MC: University Medical Center Rotterdam

Wertheim, H.F.L, Vos, M.C, Ott, A, van Belkum, A.F, Voss, A, Kluytmans, J.A.J.W, … Verbrugh, H.A. (2004). Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. The Lancet, 364(9435), 703–705. doi:10.1016/S0140-6736(04)16897-9