Congenital anomalies are expressions of abnormal growth and development. They presently form the second most frequent cause of death, after immaturity, in the perinatal period. Congenital diaphragmatic hernia (CDH) is a congenital anomaly manifesting itself in about one in 3,000 total births or one in 2,700 live births. More than 95% of the diaphragmatic defects are posterolateral ones.
For a long time CDH was considered as a purely anatomical defect of the diaphragm. But it has become clear that in many cases (ranging from 39 to 47%) it is associated with other anomalies, especially cardiac defects.
Despite improved neonatal intensive care, the overall survival rate does still not exceed 55 to 58%, and is even less in patients with associated anomalies. However, higher survival rates have been reported: Wung and coworkers reported a survival rate of 94% in a group of CDH patients who were treated with very delayed surgery and a respiratory care strategy that avoids pulmonary overdistension.

The studies reported in this thesis were conducted to investigate various, related aspects of lung development and lung injury in CDH.

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D. Tibboel (Dick) , J.C. de Jongste (Johan)
Erasmus University Rotterdam
Nederlands Astma Fonds, Koninklijke Nederlandse Academie van Wetenschappen
hdl.handle.net/1765/17879
Erasmus MC: University Medical Center Rotterdam

IJsselstijn, H. (1997, March 5). Clinical and experimental aspects of lung development and injury in congenital diaphragmatic hernia. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/17879