Congenital anomalies are expressions of abnormal growth and development. They presently form the second most frequent cause of death, after immaturity, in the perinatal period. Congenital diaphragmatic hernia (CDH) is a congenital anomaly manifesting itself in about one in 3,000 total births or one in 2,700 live births. More than 95% of the diaphragmatic defects are posterolateral ones.
For a long time CDH was considered as a purely anatomical defect of the diaphragm. But it has become clear that in many cases (ranging from 39 to 47%) it is associated with other anomalies, especially cardiac defects.
Despite improved neonatal intensive care, the overall survival rate does still not exceed 55 to 58%, and is even less in patients with associated anomalies. However, higher survival rates have been reported: Wung and coworkers reported a survival rate of 94% in a group of CDH patients who were treated with very delayed surgery and a respiratory care strategy that avoids pulmonary overdistension.

The studies reported in this thesis were conducted to investigate various, related aspects of lung development and lung injury in CDH.

Additional Metadata
Keywords diaphragmatic hernia, lung development
Promotor D. Tibboel (Dick) , J.C. de Jongste (Johan)
Publisher Erasmus University Rotterdam
Sponsor Nederlands Astma Fonds, Koninklijke Nederlandse Academie van Wetenschappen
ISBN 978-90-90-10264-1
Persistent URL hdl.handle.net/1765/17879
Citation
IJsselstijn, H. (1997, March 5). Clinical and experimental aspects of lung development and injury in congenital diaphragmatic hernia. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/17879