Multiple sclerosis (MScl) is a highly heterogeneous disease of the central nervous system, and its pathology is characterized by a combination of factors such as inflammation, demyelination and axonal damage [1, 2]. Cerebrospinal fluid (CSF) is a relatively interesting body fluid in which to search for biomarkers and diseaseassociated proteins and peptides for MScl, due to its close proximity to disease processes [3, 4]. Although multiple sclerosis has been extensively researched, the cause of the disease remains elusive.