Efficacy of statins in familial hypercholesterolaemia: A long term cohort study
Objective: To determine the efficacy of statin treatment on risk of coronary heart disease in patients with familial hypercholesterolaemia. Design: Cohort study with a mean follow-up of 8.5 years. Setting: 27 outpatient lipid clinics. Subjects: 2146 patients with familial hypercholesterolaemia without prevalent coronary heart disease before 1 January 1990. Main outcome measures: Risk of coronary heart disease in treated and "untreated" (delay in starting statin treatment) patients compared with a Cox regression model in which statin use was a time dependent variable. Results: In January 1990, 413 (21%) of the patients had started statin treatment, and during follow-up another 1294 patients (66%) started after a mean delay of 4.3 years. Most patients received simvastatin (n=1167, 33 mg daily) or atorvastatin (n=211, 49 mg daily). We observed an overall risk reduction of 76% (hazard ratio 0.24 (95% confidence interval 0.18 to 0.30), P<0.001). In fact, the risk of myocardial infarction in these statin treated patients was not significantly greater than that in an age-matched sample from the general population (hazard ration 1.44 (0.80 to 2.60), P=0.23). Conclusion: Lower statin doses than those currently advised reduced the risk of coronary heart disease to a greater extent than anticipated in patients with familial hypercholesterolaemia. With statin treatment, such patients no longer have a risk of myocardial infarction significantly different from that of the general population.
|Keywords||article, atorvastatin, cardiovascular risk, cholesterol blood level, drug efficacy, familial hypercholesterolemia, follow up, heart infarction, high density lipoprotein cholesterol, human, hydroxymethylglutaryl coenzyme A reductase inhibitor, ischemic heart disease, low density lipoprotein cholesterol, major clinical study, priority journal, simvastatin|
|Persistent URL||dx.doi.org/10.1136/bmj.a2423, hdl.handle.net/1765/18249|
|Journal||BMJ : British medical journal / British Medical Association|
Versmissen, J, Oosterveer, D.M, Yazdanpanah, M, Defesche, J.C, Basart, D.C.G, Liem, A.H, … Sijbrands, E.J.G. (2009). Efficacy of statins in familial hypercholesterolaemia: A long term cohort study. BMJ : British medical journal / British Medical Association, 338(7688), 223–226. doi:10.1136/bmj.a2423