We present a patient with a history of myelitis, who had a steroid refractory attack of CNS inflammatory demyelinating disease that developed into cerebral concentric sclerosis of Balo after plasma exchange. The acute inflammatory disease involved the spinal cord, a phenomenon rarely demonstrated. This patient fulfilled the McDonald criteria for multiple sclerosis. Plasmapheresis did not have a beneficial effect, but the patient stabilised at high EDSS after treatment with mitoxantron.

Concentric sclerosis of Balo, Expanded Disability Status Scale, MRI, Multiple sclerosis, Myelitis, Pelizaeus Merzbacher disease, Plasma exchange, adult, anamnesis, article, case report, clinical feature, corticosteroid derivative, female, gadolinium, human, mitoxantrone, myelitis, neurologic examination, nuclear magnetic resonance imaging, plasmapheresis, priority journal
dx.doi.org/10.1016/j.jns.2008.12.030, hdl.handle.net/1765/18270
Journal of the Neurological Sciences
Erasmus MC: University Medical Center Rotterdam

Kreft, K.L, Mellema, S.J, & Hintzen, R.Q. (2009). Spinal cord involvement in Balo's concentric sclerosis. Journal of the Neurological Sciences, 279(1-2), 114–117. doi:10.1016/j.jns.2008.12.030