Glycated haemoglobin (HbA1c) is considered the best index of glycaemic control in established diabetes. It may also be useful in the diagnosis of diabetes and as a screening tool. Little is known about the distribution of HbA1c in healthy children and its predictors. The aim of this study is to describe the distribution of HbA1c in non-diabetic Dutch children aged 8-9 years and to investigate potential associations of HbA1c in this group. Methods : HbA1c was measured in 788 non-diabetic children aged 8-9 years participating in the PIAMA birth cohort study. Data on parents and children were collected prospectively by questionnaires. Weight, height and waist and hip circumference of the children were measured when blood samples were taken. Results : Mean (sd) HbA 1c was 4.9 ± 0.33%, range 3.5-6.0%. HbA1c was significantly higher in boys (4.9 ± 0.31 vs. 4.9 ± 0.33%) and in children of mothers with gestational diabetes (5.0 ± 0.37 vs. 4.9 ± 0.32%). We found a significant inverse association between HbA 1c and haemoglobin (regression coefficient: -0.169 (95% CI -0.221 to -0.118), P < 0.001). HbA1c was not significantly associated with age, body mass index, waist circumference, parental diabetes or maternal body mass index. Conclusions : We found no significant relation between known risk factors for Type 2 diabetes and HbA1c at age 8-9 years. Moreover, there was a significant inverse association between haemoglobin and HbA 1c. These results suggest that HbA1c may not only reflect the preceding blood glucose levels, but seems to be determined by other factors as well.

Children, Glycated haemoglobin, Netherlands, Non-diabetic, article, blood sampling, child, cohort analysis, female, glucose, glucose blood level, hemoglobin A1c, hemoglobin blood level, human, human experiment, male, non insulin dependent diabetes mellitus, normal human, pregnancy diabetes mellitus, school child,
Diabetic Medicine: journal of diabetes UK
Erasmus MC: University Medical Center Rotterdam

Jansen, H, Wijga, A.H, Smit, H.A, Scholtens, S, Kerkhof, M, Koppelman, G.H, … Stolk, R.P. (2009). HbA1c levels in non-diabetic Dutch children aged 8-9 years: The PIAMA birth cohort study: Original Article: Metabolism. Diabetic Medicine: journal of diabetes UK, 26(2), 122–127. doi:10.1111/j.1464-5491.2008.02641.x