The objective of this thesis was to quantify three-dimensional ocular stability in response to head movements in healthy human subjects and in patients with various types of peripheral vestibular disorders. Despite a large increase in our knowledge from animal and human studies about the neuronal circuitry that regulates three-dimensional (3D) vestibular organization (for a recent review see Angelaki and Cullen 2008), its application to clinical practice is still a long way ahead. In order to bridge this gap, we explored in healthy subjects the naturally occurring variability in 3D vestibulo-ocular stabilization and compared these results with changes that occur in 3D vestibulo-ocular stabilization in patients with various types of unilateral vestibular disorders.

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NWO, ALK-Abelló B.V., Atos Medical B.V., GlaxoSmithKline, Schering-Plough, Nederlandse Vereniging voor KNO-heelkunde en Heelkunde van het Hoofd- Halsgebied.
L. Feenstra (Louw) , J.G.G. Borst (Gerard)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Goumans, J. (2010, April 14). Three-Dimensional Vestibulo-Ocular Reflex in Humans: a Matter of Balance. Retrieved from