Drug safety alert generation and overriding in a large Dutch university medical centre
Pharmacoepidemiology and Drug Safety: an international journal , Volume 18 - Issue 10 p. 941- 947
PURPOSE: To evaluate numbers and types of drug safety alerts generated and overridden in a large Dutch university medical centre. METHODS: A disguised observation study lasting 25 days on two internal medicine wards evaluating alert generation and handling of alerts. A retrospective analysis was also performed of all drug safety alerts overridden in the hospital using pharmacy log files over 24 months. RESULTS: In the disguised observation study 34% of the orders generated a drug safety alert of which 91% were overridden. The majority of alerts generated (56%) concerned drug-drug interactions (DDIs) and these were overridden more often (98%) than overdoses (89%) or duplicate orders (80%). All drug safety alerts concerning admission medicines were overridden.Retrospective analysis of pharmacy log files for all wards revealed one override per five prescriptions. Of all overrides, DDIs accounted for 59%, overdoses 24% and duplicate orders 17%. DDI alerts of medium-level seriousness were overridden more often (55%) than low-level (22%) or high-level DDIs (19%). In 36% of DDI overrides, it would have been possible to monitor effects by measuring serum levels. The top 20 of overridden DDIs accounted for 76% of all DDI overrides. CONCLUSIONS: Drug safety alerts were generated in one third of orders and were frequently overridden. Duplicate order alerts more often resulted in order cancellation (20%) than did alerts for overdose (11%) or DDIs (2%). DDIs were most frequently overridden. Only a small number of DDIs caused these overrides. Studies on improvement of alert handling should focus on these frequently-overridden DDIs.
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|Pharmacoepidemiology and Drug Safety: an international journal|
|Organisation||Erasmus School of Health Policy & Management (ESHPM)|
van der Sijs, I.H, Mulder, A, van Gelder, T, Aarts, J.E.C.M, Berg, M, & Vulto, A.G. (2009). Drug safety alert generation and overriding in a large Dutch university medical centre. Pharmacoepidemiology and Drug Safety: an international journal, 18(10), 941–947. doi:10.1002/pds.1800