Comparison of potential risk factors for medication errors with and without patient harm [Vergelijking van potentiële risicofactoren voor medicatiefouten met en zonder schade]
Pharmaceutisch Weekblad , Volume 145 - Issue 3 p. 2- 6
Objective: To compare determinants for medication errors leading to patient harm with determinants for medication errors without patient harm. Design: A two-way case-control design was used to identify determinants for medication errors without harm (substudy 1) and determinants for medication errors causing harm (substudy 2). Methods: Data of patients admitted to five internal medicine wards of two Dutch hospitals during five months were collected prospectively by chart review. Medication errors were identified and classified by two pharmacists. Consensus between five pharmacists was reached on the causal relationship between medication errors and patient harm. Data analysis was performed by multivariate logistic regression. Results: We included 7286 medication orders, of which 3315 without errors (controls), and identified 5622 medication errors without harm (cases substudy 1) and 102 medication errors causing harm (cases substudy 2). Hospital, ward and the therapeutic class of anti-infectives were associated with both medication errors without harm [hospital odds ratio (OR) 1.40; 95% confidence interval (CI95) 1.21-1.63, TweeSteden hospital (TSz) geriatrics OR 2.03; CI95 1.73-2.38, TSz general internal medicine OR 1.44; CI95 1.23-1.69, and anti-infectives OR 1.28; CI95 1.06-1.56] and medication errors with harm (hospital OR 4.91; CI95 3.02-7.79, TSz geriatrics OR 5.76; CI95 2.52-13.15, TSz general internal medicine OR 1.44; CI95 2.82-15.02, and anti-infectives OR 4.20; CI95 2.24-7.90). Conclusions: This study shows that organisational determinants (hospital, ward) are comparable for medication errors with and without harm. For conclusions on patient-related and medication-related determinants studies with larger sample sizes are needed.
|article, health care organization, hospital admission, human, medical error, patient safety, prospective study, risk factor|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Zaal, R.J, van Doormaal, J.E, Lenderink, B.W, Mol, P.G.M, Kosterink, J.G.W, Egberts, T.C.G, … van den Bemt, P.M.L.A. (2010). Comparison of potential risk factors for medication errors with and without patient harm [Vergelijking van potentiële risicofactoren voor medicatiefouten met en zonder schade]. Pharmaceutisch Weekblad, 145(3), 2–6. Retrieved from http://hdl.handle.net/1765/19545