Xenogeneic liver transplantation: Potential applications and pitfalls in a discordant rodent model

After the initial focus on the biology of graft rejection and its prevention, now the main concern of transplantation research is donor shortage. In 1979, the introduction of cyc1osporine A (esA) improved the outcome of clinical organ transplantation significantly. Technical developments and experience fhrther increased survival rates. Therefore, serious efforts have been made to raise the amount of potential donors. These efforts included public awareness campaigns, altered donation legislation and expanded clinical donation programs [1,2]. Despite these initiatives, there was no reduction in the number of patients awaiting transplantation. Thus, interest has focussed on tec1mical and scientific advances to broaden the possibilities of mastering this problem. The development of artificial organs and progress in cloning techniques might lead to a solution. Xenotransplantation, transplantation of organs and tissues from one species to another, including man, also holds a high potential. It could offer the opportunity of access to an indefinite pool of donors.

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