Background: Tuberculosis (TB) constitutes one-quarter of all avoidable deaths in developing countries. In the Eastern Cape, South Africa, TB is a public health problem of epidemic proportion. Poor compliance and frequent interruption to treatment are associated with increased transmission rates, morbidity, and costs to TB control programs. This study explored determinants of (non-)compliance from the patients perspective. Methods: Semi-structured interviews were conducted with patients (33 treatment compliers and 34 treatment non-compliers) and 14 community health workers from local community clinics and the hospital in the township of Grahamstown, Eastern Cape, South Africa. Q-methodology was used. Patients rank ordered 32 opinion statements describing determinants of treatment compliance fromthe TB adherencemodel. By-person factor analysis was used to explore patterns in the rankings of statements by compliers and non-compliers. These patterns were interpreted and described as patient views on determinants of compliance with treatment. Patients and community health workers selected the top five determinants of compliance and non-compliance. Results: Compliers believed that completing treatment would cure them of B. Economic prospects were crucial for compliance. Compliers felt that the support of the government disability grant helped with compliance. Noncompliers believed that stigmatization had the greatest impact on noncompliance, together with the burden of disease, the arrangements involved ith receiving treatment, restrictions accompanying treatment, and the association of TB with HIV/AIDS infection. Conclusions: Stigmatization makes TB a 'social disease'. Individual motivation and self-efficacy appear to have a considerable effect on compliance, but, for non-compliers, the general lack of job prospects and being able to provide for themselves or their family also makes TB very much an 'economic disease'.

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Keywords Patient-compliance, Patient-preference, Tuberculosis, treatment
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Journal The Patient: patient-centered outcomes research
Cramm, J.M, van Exel, N.J.A, Møller, V, & Finkenflügel, H.J. (2010). Patient views on determinants of compliance with tuberculosis treatment in the Eastern Cape, South Africa: An application of Q-methodology. The Patient: patient-centered outcomes research, 3(3), 159–172. doi:10.2165/11531900