With great interest we read the article by Lam et al. from the Sydney Melanoma Unit on the multimodality approach to the sentinel node (SN).
This study is the first to describe in a detailed manner that in melanoma the obstruction of lymphatic drainage by the tumor can also lead to a false-negative SN biopsy, which might have easily been avoided, if an ultrasound (US) was performed preoperatively. [...]

aspiration cytology, classification algorithm, echography, false negative result, histopathology, human, human tissue, letter, lymphatic drainage, lymphoscintigraphy, metastasis, preoperative evaluation, priority journal, sentinel lymph node biopsy
dx.doi.org/10.1097/CMR.0b013e32833adf13, hdl.handle.net/1765/20192
Melanoma Research: a journal for basic, translational and clinical research in melanoma
Erasmus MC: University Medical Center Rotterdam

Voit, C, van Akkooi, A.C.J, Schäfer-Hesterberg, G, Sterry, W, & Eggermont, A.M.M. (2010). The value of preoperative ultrasound (after lymphoscintigraphy) in conjunction with pre-sentinel lymph node biopsy fine-needle aspiration outweighs the usage of ultrasound alone in conjunction with lymphoscintigraphy: The need for an algorithm. Melanoma Research: a journal for basic, translational and clinical research in melanoma, 20(4), 357–359. doi:10.1097/CMR.0b013e32833adf13