Objective: The purpose of this study was to compare clinical outcome and health related quality of life (HRQOL) 5 years after uterine artery embolization (UAE) or hysterectomy in the treatment of menorrhagia caused by uterine fibroids. Study design: Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires. Results: Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4%) had undergone a hysterectomy because of insufficient improvement of complaints (24.7% after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function. Conclusion: UAE is a well-established alternative to hysterectomy about which patients should be counseled.

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Keywords fibroid tumor, hysterectomy, menorrhagia, uterine artery embolization
Persistent URL dx.doi.org/10.1016/j.ajog.2010.01.049, hdl.handle.net/1765/20301
Journal American Journal of Obstetrics & Gynecology
Note Article in press - dd August 2010
van der Kooij, S.M, Hehenkamp, W.J.K, Volkers, N.A, Birnie, E, Ankum, W.M, & Reekers, J.A. (2010). Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial. American Journal of Obstetrics & Gynecology, 203(2). doi:10.1016/j.ajog.2010.01.049